autocamtide-2-related inhibitory peptide Related - peptide-sciences-discount Myristoylated autocamtide-2-related inhibitory peptide acetate Autocamtide-2-Related Inhibitory Peptide: A Potent Modulator of Calmodulin-Dependent Protein Kinase II

peptide-sciences-discount-code-first-order Autocamtide-2-related inhibitory peptide (AIP) stands out as a highly specific and potent inhibitor, primarily targeting the crucial enzyme calmodulin-dependent protein kinase II (CaMKII). This synthetic peptide has garnered significant attention in scientific research for its ability to precisely control the biological activity of this key kinase. Understanding the properties and applications of autocamtide-2-related inhibitory peptide is essential for researchers delving into cellular signaling pathways, particularly those involving CaMKII.作者：A Ishida·1998·被引用次数：77—We have recently demonstrated that a syntheticpeptide, designated as AIP, a nonphosphorylatable analog of apeptidesubstrate,autocamtide-2[5] ...

At its core, autocamtide-2-related inhibitory peptide functions as a CaM kinase II inhibitor.Autocamtide-2-Related Inhibitory Peptide (AIP); CaMKII ... Its efficacy is quantified by an impressive IC50 of 40 nM, indicating a very low concentration is required to inhibit 50% of CaMKII activity.作者：X Feng·2023·被引用次数：10—The results showed that AIP could inhibit the expression of the fibrosis markers fibronectin, collagen I, matrix metalloproteinase2, and α-smooth muscle actin ... This high potency, coupled with its selectivity, makes it an invaluable tool. Unlike broader kinase inhibitors, autocamtide-2-related inhibitory peptide exhibits specificity, meaning it does not significantly affect other important protein kinases such as protein kinase A (PKA) or protein kinase C (PKC).Autocamtide-2-related inhibitory peptide | CaMKII Inhibitor This targeted action allows researchers to isolate the effects of CaMKII inhibition without confounding results from other signaling cascades.

The development of autocamtide-2-related inhibitory peptide is rooted in its design as a nonphosphorylatable analog of autocamtide-2. This structural modification is key to its inhibitory function, as it can bind to the active site of CaMKII and prevent its catalytic activityAutocamtide-2-related inhibitory peptide. The molecular weight of autocamtide-2-related inhibitory peptide is approximately 1611.76, a characteristic of its peptide nature.Autocamtide-2 Related Inhibitory Peptideis a calmodulin-dependent protein kinase II (CaMKII) inhibitor(IC 50 = 40 nM) that contains the autophosphorylation ...

Further enhancing its utility, a myristoylated autocamtide-2-related inhibitory peptide variant existsAutocamtide-2-related inhibitory peptideis a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC 50 = 40 nM).. The addition of a myristoyl group increases the cell permeability of the peptide, allowing it to more readily enter cells and exert its inhibitory effects intracellularly. This myristoylated autocamtide-2-related inhibitory peptide acetate is particularly useful for in-vitro studies investigating cellular processes.Type-II Kinase Inhibitor Docking, Screening, and Profiling ... - NIH Researchers can try our high quality amino acids, resins and reagents to synthesize or acquire these specialized forms for their experiments.Autocamtide-2 Related Inhibitory Peptide, Myristoylated

The scientific literature highlights the diverse applications of autocamtide-2-related inhibitory peptide. For instance, it has been employed to inhibit calmodulin kinase II (CaMKII) action in studies involving infected macrophages, demonstrating its role in modulating cellular responses to pathogens.Buy GK8833 -Autocamtide-2-related inhibitory peptide(167114-91-2) online from Glentham Life Sciences, a manufacturer and supplier of fine chemicals. Research has also indicated that CaMKII inhibition by compounds like myristoylated autocamtide-2-related inhibitory peptide can promote neuronal apoptosis, suggesting its involvement in neurological processes and potential therapeutic avenues. Furthermore, studies have shown that AIP can inhibit the expression of fibrosis markers such as fibronectin, collagen I, matrix metalloproteinase-2, and $\alpha$-smooth muscle actin, indicating its potential role in conditions involving tissue remodelingAutocamtide-2-related inhibitory peptideis a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC 50 = 40 nM)..

The CAS Number for autocamtide-2-related inhibitory peptide is 167114-91-2, a unique identifier crucial for procurement and regulatory purposes. Available in various forms, including trifluoroacetate salt (autocamtide-2-related inhibitory peptide TFA), this high-purity protein kinase inhibitor ensures reliable performance for precise signaling pathway modulation.

In summary, autocamtide-2-related inhibitory peptide is a sophisticated molecular tool. Its ability to act as a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor makes it indispensable for researchers investigating the multifaceted roles of CaMKII in cellular function, disease, and physiological processes.Autocamtide-2 Related Inhibitory Peptideis a calmodulin-dependent protein kinase II (CaMKII) inhibitor(IC 50 = 40 nM) that contains the autophosphorylation ... Whether in its standard form or as a cell-permeable myristoylated autocamtide-2-related inhibitory peptide, this inhibitory peptide offers a precise method to explore and manipulate critical biological pathways.Autocamtide-2-related inhibitory peptide (TFA)is a highly specific and potent inhibitor of CaMKIIwith an IC50 of 40 nM. - Mechanism of Action & Protocol. The exploration of analogs, such as [Ala9]-Autocamtide-2, further underscores the ongoing research and development in this area of peptide-based kinase inhibition.