peptide y y is released in response to feeding - PeptideYY foods PYY is best known as an anorectic peptide Understanding Peptide YY (PYY): A Comprehensive Exploration of its Role in Appetite and Beyond

PeptideYY foods Peptide YY (PYY), also recognized as peptide tyrosine tyrosine, is a fascinating peptide hormone with significant implications for human health, particularly in the regulation of appetite and digestionCritical role for peptide YY in protein-mediated satiation .... This article delves into the multifaceted nature of PYY, exploring its origins, functions, and potential therapeutic applications, drawing upon scientific research and established biological knowledge.

The Genesis and Structure of Peptide YY

Peptide YY (PYY) is a 36-amino acid peptide that in humans is encoded by the PYY gene作者：E Karra·2008·被引用次数：459—There is emerging evidence thatPYY3–36 may partly mediate the reduced appetite and weight loss benefitsobserved post-gastric bypass surgery.. It belongs to the pancreatic polypeptide family, which also includes pancreatic polypeptide (PP) and neuropeptide Y (NPY). PYY is primarily synthesized and secreted by L-cells located in the lining of the distal gastrointestinal tract, specifically the ileum and colon, in response to the presence of nutrients. Upon ingestion of food, particularly fats and carbohydrates entering the small intestine, PYY is released into the bloodstream. This release is a crucial component of the complex neuroendocrine control process governing digestion and satiety.

Peptide YY's Multifaceted Functions

The primary and most well-documented role of Peptide YY (PYY) is its influence on appetite and food intake. PYY is best known as an anorectic peptide, meaning it acts to suppress appetite. This is achieved through its interaction with neuropeptide Y receptors, specifically acting as a neuropeptide Y2 receptor agonistPeptide YY - an overview. By binding to these receptors, PYY signals to the brain, indicating satiety and reducing the desire to eat.2007年10月21日—Peptide YY (3-36), a synthetic human PYY 3-36,is a compound being evaluated for the treatment of obesity. It reduces appetite and increases ...

Emerging evidence suggests that PYY3–36 may partly mediate the reduced appetite and weight loss benefits observed after procedures like gastric bypass surgery. This highlights PYY's potential role in weight management strategies. Furthermore, PYY has been investigated as a compound being evaluated for the treatment of obesity, due to its ability to reduce appetite and increase feelings of fullness. Studies have shown that high-protein intake induced the greatest release of the anorectic hormone peptide YY (PYY) and the most pronounced satiation.作者：BJ Gheller·2019·被引用次数：12—Peptide YY (PYY)is considered a gut peptidewith roles in post-prandial appetite and glucose regulation. Circulating PYY protein levels ...

Beyond appetite regulation, Peptide YY in humans has a role in food ingestion, gut motility and insulin secretion. It is involved in the modulation of glucose metabolism, encompassing both insulin and glucagon secretion. This underscores PYY's function as a pleiotropic gut hormonePeptide YY | Hormones. It also plays a part in suppressing appetite and has been associated with conditions like obesity.

Moreover, PYY has other physiological effects:

* Inhibits exocrine pancreatic secretion: This action contributes to the regulation of digestive enzyme release.

* Vasoconstrictory action: PYY can cause blood vessels to narrowPeptide YY (3-36): Uses, Interactions, Mechanism of Action.

* Inhibits jejunal and colonic mobility: This influences the movement of food through the intestines.Peptide YY(PYY), a member of the pancreatic polypeptide family, has roles in gastric acid and pancreatic enzyme secretion and gastrointestinal motility ...

Peptide YY and Related Concepts

The study of Peptide YY (PYY) often involves understanding its relationship with other key hormones and receptorsPeptide YY(PYY), a member of the pancreatic polypeptide family, has roles in gastric acid and pancreatic enzyme secretion and gastrointestinal motility .... As mentioned, it is closely related to neuropeptide Y (NPY) and shares sequential homology with Human Pancreatic Polypeptide (HPP). They all act through the Y receptor family, including Y1, Y2, Y4, Y5, and Y6 receptors. PYY (3-36), a specific fragment of the hormone, is a Y2 selective agonist, exhibiting distinct binding affinities compared to the full-length peptide.

The interplay between Peptide YY and GLP-1 (Glucagon-Like Peptide-1) is also an area of research, as both are gut hormones involved in the regulation of appetite and glucose homeostasis. While PYY is primarily known for its satiety signals, GLP-1 also plays a role in insulin secretion and slowing gastric emptying.

Research and Clinical Significance

The scientific community continues to explore the diverse roles of Peptide YY (PYY). Research has indicated that PYY is a pancreatic polypeptide hormone with a significant impact on physiological processes.Peptide YY (3-36) (porcine)is a Y2 selective agonist. IC50 values are 0.11 and 1050 nM for inhibition of125I-PYY binding to Y2 and Y1 receptors respectively. Some studies even suggest that PYY also uniquely represents the possible cause of obesity as well as its ultimate cure, as obese individuals may exhibit altered PYY levels or responsivenessPyy - Peptide YY - Mus musculus (Mouse) | UniProtKB.

The investigation into PYY extends to various health conditions. For instance, research has explored Peptide YY in Type 2 Diabetes, examining its potential role in modulating glucose metabolism.

Conclusion

Peptide YY (PYY) is a critical gut hormone involved in a complex array of bodily functions, most notably appetite regulation. Its release post-meal signals satiety to the brain, contributing to a sense of fullness and reduced food intake. As research progresses, the full scope of PYY's influence on metabolism, gastrointestinal health, and its potential as a therapeutic target for conditions like obesity continues to unfold作者：BJ Gheller·2019·被引用次数：12—Peptide YY (PYY)is considered a gut peptidewith roles in post-prandial appetite and glucose regulation. Circulating PYY protein levels .... Understanding PYY provides valuable insights into the intricate mechanisms that govern our body's response to food and overall metabolic balance.Peptide YY(PYY), a member of the pancreatic polypeptide family, has roles in gastric acid and pancreatic enzyme secretion and gastrointestinal motility ...